proxisome prolifrator-activated receptors alpha and delta in diabetic cardiomyopathy

Proxisome prolifrator-activated receptors alpha and delta in diabetic cardiomyopathy

Peraxisome prolifrator-activated receptors (PPARs) are a group of nuclear receptors comprising three isoforms termed alpha, beta/delta and gamma. PPARs can modulate metabolic processes especially fatty acid (FA) metabolisms via exerting transcriptional control on activating genes involved in fuel utilization. Thus, they can exert positive role in controlling chronic diseases such as diabetes. A...

Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy

Diabetic nephropathy is a leading cause of end-stage renal disease, which is increasing in incidence worldwide, despite intensive treatment approaches such as glycemic and blood pressure control in patients with diabetes mellitus. New therapeutic strategies are needed to prevent the onset of diabetic nephropathy. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear t...

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta.

Fatty acids (FAs) and their derivatives are essential cellular metabolites whose concentrations must be closely regulated. This implies that regulatory circuits exist which can sense changes in FA levels. Indeed, the peroxisome proliferator-activated receptor alpha (PPARalpha) regulates lipid homeostasis and is transcriptionally activated by a variety of lipid-like compounds. It remains unclear...

Are peroxisome proliferator-activated receptors new therapeutic targets in diabetic and non-diabetic nephropathies?

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Diabetic Cardiomyopathy and Adiponectin

People with DM can develop heart dysfunction called diabetic cardiomyopathy [5]. This is characterized by dilation and hypertrophy of the myocardium, accompanied by systolic dysfunction and / or left ventricular diastolic and their presence is independent of ischemic heart disease or hypertension coexistence [7]. Although diabetic cardiomyopathy is a chronic subclinical condition [8], eventuall...

Diabetic cardiomyopathy